And now the former X Factor judge has started work on the film in Atlanta, Georgia, alongside Cameron Diaz.
The 28-year-old star was spotted on the set, showing off her figure in a tight black Emilio Pucci lace dress and sky-high heels as she made her way to film her first scenes.
The film – whose cast also includes actors Dennis Quaid, Chris Rock and Matthew Morrison - chronicles the lives of four couples as they prepare to become parents.
And, in what could be construed as a side-swipe at Simon Cowell after she was sacked from X Factor USA, Cheryl will play a TV talent show judge for her cameo role in the film.
Cameron plays Jules who auditions in an X Factor-style contest in front of the TV talent show judge - Cheryl Cole's character.
Cheryl Cole is said to have initially impressed Hollywood film bosses during a four-day appearance at the Cannes Film Festival in May.
A film source revealed to the Daily Mail earlier this year: ‘This is a bit of fun for Cheryl. She will film the scenes imminently and is really looking forward to it.
'It doesn’t mean she suddenly wants to become actress. It was just an opportunity that has come up while she has been having some down time and she thought it would be great fun to take part.’
A spokesperson for the singer confirmed at the time: 'Cheryl Cole is confirmed for a small cameo appearance in the film What to Expect When You're Expecting.'
Meanwhile, in a recent interview with The Hollywood Reporter, Simon Cowell said he wouldn't hesitate to offer Cheryl a role on another of his TV projects.
Defending his decision to replace Cheryl with Nicole Scherzinger in the US, Cowell said: 'You're not drowning puppies here.
'You're offering someone who's got millions of dollars more money and more work. And if people think that's cruel, then they can do that to me on a daily basis. I'll take it twice a day.'
Cowell also confirmed that he offered Cheryl the chance to return to UK X Factor, but negotiations fell apart and they hadn't spoken since.
He said: 'She missed the deadline which meant she'd lost the UK show. I asked her manager Will.i.am, "How does she feel about it?" He said, "It's none of your concern."
'I never heard from her... I think her silence was quite damning.'